Announcing an important update to the EscRisk app, with provisional efforts to trace the therapeutic index idea within the oncology dose-finding literature…
Package #precautionary thus gains ease of use by its core audience. 2/@AmanChauhanMD @apolo_andrea @DrDonaldHarvey @geosullivanc @lillian_siu @PatelOncology @phase1oncomd @RGroisberg @ShirajSenMDPhD @ShuchiGulati @tmprowell @udai_banerji @VivekSubbiahhttps://t.co/dki9hn4snq
— David C. Norris, MD moved to Mastodon 🦣 (@davidcnorrismd) July 7, 2021
It’s recently come to my attention that some phase 1 trialists have previously recognized a pivotal role for TI notions in trial design. A 2014 review by Hansen, Graham, Pond & @lillian_siu stresses therapeutic index/window as paramount. 4/https://t.co/WN8dR47guj pic.twitter.com/p9iwlvYVBQ
— David C. Norris, MD moved to Mastodon 🦣 (@davidcnorrismd) July 7, 2021
So #TherapeuticIndex intuitions have clearly been present in this literature for at least a decade. (Welcoming citations I may have missed!) But as far as I know, the slider in this app represents the first attempt to render these intuitions formally for use by trialists. 6/6
— David C. Norris, MD moved to Mastodon 🦣 (@davidcnorrismd) July 7, 2021