1
2
3
4
5
6
7
8
9
10
11
12
13
14
15
16
17
18
19
20
21
22
23
24
1
2
3
4
5
6
7
0.25
0.35
0.49
0.69
0.96
1.34
1.88
1
2
3
4
5
6
7
8
9
10
Participant number
Dose level
DLT assessment period
Dose (mg)
1.0
0.8
0.6
0.4
0.2
0.0
1
2
3
4
5
6
7
Fraction tolerant
Dose level